A rare codon-based translational program of cell proliferation

Abstract Background The speed of translation elongation is primarily determined by the abundance of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are translated. As the nature of tRNA pools and modifications can vary across biological conditions, codon elongation rates...

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Autors principals: Joao C. Guimaraes, Nitish Mittal, Alexandra Gnann, Dominik Jedlinski, Andrea Riba, Katarzyna Buczak, Alexander Schmidt, Mihaela Zavolan
Format: Artigo
Idioma:Inglês
Publicat: BMC 2020-02-01
Col·lecció:Genome Biology
Matèries:
Cell proliferation
Translation control
Codon usage
Rare codons
Translation elongation
tRNA pools
Accés en línia:http://link.springer.com/article/10.1186/s13059-020-1943-5
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