A rare codon-based translational program of cell proliferation

Abstract Background The speed of translation elongation is primarily determined by the abundance of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are translated. As the nature of tRNA pools and modifications can vary across biological conditions, codon elongation rates...

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Detalhes bibliográficos
Main Authors: Joao C. Guimaraes, Nitish Mittal, Alexandra Gnann, Dominik Jedlinski, Andrea Riba, Katarzyna Buczak, Alexander Schmidt, Mihaela Zavolan
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-02-01
Colecção:Genome Biology
Assuntos:
Cell proliferation
Translation control
Codon usage
Rare codons
Translation elongation
tRNA pools
Acesso em linha:http://link.springer.com/article/10.1186/s13059-020-1943-5
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