A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.

Flavivirus RNA replication occurs within a replication complex (RC) that assembles on ER membranes and comprises both non-structural (NS) viral proteins and host cofactors. As the largest protein component within the flavivirus RC, NS5 plays key enzymatic roles through its N-terminal methyltransfera...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yongqian Zhao, Tingjin Sherryl Soh, Jie Zheng, Kitti Wing Ki Chan, Wint Wint Phoo, Chin Chin Lee, Moon Y F Tay, Kunchithapadam Swaminathan, Tobias C Cornvik, Siew Pheng Lim, Pei-Yong Shi, Julien Lescar, Subhash G Vasudevan, Dahai Luo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science (PLoS) 2015-03-01
Cyfres:PLoS Pathogens
Mynediad Ar-lein:http://europepmc.org/articles/PMC4361662?pdf=render
Tagiau: Ychwanegu Tag
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