Hormone-sensitive lipase protects adipose triglyceride lipase-deficient mice from lethal lipotoxic cardiomyopathy

Lipid droplets (LDs) are multifunctional organelles that regulate energy storage and cellular homeostasis. The first step of triacylglycerol hydrolysis in LDs is catalyzed by adipose triglyceride lipase (ATGL), deficiency of which results in lethal cardiac steatosis. Although hormone-sensitive lipas...

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Detalhes bibliográficos
Main Authors: Mika Yamada, Jinya Suzuki, Satsuki Sato, Yasuo Zenimaru, Rie Saito, Tadashi Konoshita, Fredric B. Kraemer, Tamotsu Ishizuka
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:Journal of Lipid Research
Assuntos:
apoptosis
beta-oxidation
ceramides
FA
lipid droplets
lipotoxicity
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S002222752200027X
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