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Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice

Active co-delivery of tumor antigens (Ag) and α-galactosylceramide (α-GalCer), a potent agonist for invariant Natural Killer T (iNKT) cells, to cross-priming CD8α+ dendritic cells (DCs) was previously shown to promote strong anti-tumor responses in mice. Here, we designed a nanoparticle-based vaccin...

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Principais autores: Jing Huang, Jing Zhou, Reem Ghinnagow, Toshiyuki Seki, Sho Iketani, Daphnée Soulard, Patrick Paczkowski, Yukiko Tsuji, Sean MacKay, Luis Javier Cruz, François Trottein, Moriya Tsuji
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-08-01
Serier:Frontiers in Immunology
Fag:
nanovaccine
targeting
human CD141+ DCs
iNKT cells
α-galactosylceramide
CD8+ T cells
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2020.02043/full
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