Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human hepatocyte tropism and neutralizing antibodies (Nab...

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Autores principales:	Xiaolei Pei, Wenwei Shao, Allene Xing, Charles Askew, Xiaojing Chen, Caibin Cui, Yasmina L. Abajas, David A. Gerber, Elizabeth P. Merricks, Timothy C. Nichols, Wuping Li, R. Jude Samulski, Chengwen Li
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2020-09-01
Colección:	Molecular Therapy: Methods & Clinical Development
Materias:	AAV human hepatocyte tropism Nabs chimeric mice
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S232905012030125X
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