Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis

ObjectiveRheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis. Intra-articular gene delivery to block proinflammatory cytokines has been studied in pre-clinical models and human clinical trials. It has been demonstrated that the level of programmed death-ligand 1 (P...

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Autors principals:	Wenjun Li, Junjiang Sun, Susi Liu Feng, Feng Wang, Michael Z. Miao, Eveline Y. Wu, Shannon Wallet, Richard Loeser, Chengwen Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-03-01
Col·lecció:	Frontiers in Immunology
Matèries:	PD-L1 rheu matoid arthritis AAV (Adeno-associated virus) Inflammation Gene Therapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116084/full
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