Rationally engineered novel AAV capsids for intra-articular gene delivery

Intra-articular adeno-associated virus (AAV) gene therapy has been explored as a potential strategy for joint diseases. However, concerns of low transduction efficacy, off-target expression, and neutralizing antibodies (Nabs) still need to be addressed. In this study, we demonstrated that AAV6 was t...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Wenjun Li, Susi Liu Feng, Lizette Herrschaft, R. Jude Samulski, Chengwen Li
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2024-03-01
Serier:	Molecular Therapy: Methods & Clinical Development
Fag:	AAV engineering joint Nab transduction rational design
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2329050124000275
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!