APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling

The exonuclease Apurinic/apyrimidinic endonuclease 1 (APE1) is important for processing matched/mismatched terminus during DNA repair. Here the authors resolve the X-ray crystallography structures of APE1 with varied dsDNAs substrates to assay the nuclease activity.

Detalhes bibliográficos

Principais autores:	Tung-Chang Liu, Chun-Ting Lin, Kai-Cheng Chang, Kai-Wei Guo, Shuying Wang, Jhih-Wei Chu, Yu-Yuan Hsiao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2021-01-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-020-20853-2
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