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Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activity

Background Immune checkpoint inhibitors (ICIs) have improved outcomes and extended patient survival in several tumor types. However, ICIs often induce immune-related adverse events (irAEs) that warrant therapy cessation, thereby limiting the overall effectiveness of this class of therapeutic agents....

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Principais autores: Brian S Henick, Xizi Hu, Shoiab M Bukhari, Carly Tymm, Kieran Adam, Shalom Lerrer, Robert J Winchester, Adam Mor
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2024-03-01
Serier:Journal for ImmunoTherapy of Cancer
Online adgang:https://jitc.bmj.com/content/12/3/e008482.full
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