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Data-driven computational modeling of CAR-T cell function

IntroductionThe complex dynamics of chimeric antigen receptor T-cell (CAR-T cell) cytotoxicity and proliferation are potential factors that influence the clinical response to CAR-T therapy. The patient-specific functionality of CAR-T products play a role in these dynamics. CAR-T products comprise ph...

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Autori principali: Viren Shah, Justin A. Womack, Katie Palen, Bryon D. Johnson, Peiman Hematti, Tyce J. Kearl, Nirav N. Shah, Scott S. Terhune, Ranjan K. Dash
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-05-01
Serie:Frontiers in Immunology
Soggetti:
CAR-T cell cytotoxicity kinetics
CAR-T cells
CAR-T cellular differentiation
CAR-T therapy
chimeric antigen receptor
computational modeling
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1707783/full
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