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Deciphering the importance of culture pH on CD22 CAR T-cells characteristics

Abstract Background Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization of protocols for CAR T-cell manufacturing, critical parameters of cell...

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Principais autores: Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill, Robert P. Somerville, Nirali N. Shah, David F. Stroncek, Ping Jin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-04-01
coleção:Journal of Translational Medicine
Assuntos:
Chimeric antigen receptor (CAR) T-cells
pH
Clinical manufacturing
Immunotherapy
Acesso em linha:https://doi.org/10.1186/s12967-024-05197-5
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