Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells

Cryopreservation of chimeric antigen receptor (CAR) T cells facilitates shipment, timing of infusions, and storage of subsequent doses. However, reports on the impact of cryopreservation on CAR T cell efficacy have been mixed. We retrospectively compared clinical outcomes between patients who receiv...

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Huvudupphov:	Alexandra Dreyzin, Sandhya R. Panch, Haneen Shalabi, Bonnie Yates, Steven L. Highfill, Ping Jin, David Stroncek, Nirali N. Shah
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2023-03-01
Serie:	Molecular Therapy: Methods & Clinical Development
Ämnen:	cell therapy CAR T clinical outcomes cryopreservation CAR T manufacturing cytokine release syndrome
Länkar:	http://www.sciencedirect.com/science/article/pii/S2329050122001772
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