Deciphering the importance of culture pH on CD22 CAR T-cells characteristics

Abstract Background Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization of protocols for CAR T-cell manufacturing, critical parameters of cell...

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主要な著者:	Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill, Robert P. Somerville, Nirali N. Shah, David F. Stroncek, Ping Jin
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2024-04-01
シリーズ:	Journal of Translational Medicine
主題:	Chimeric antigen receptor (CAR) T-cells pH Clinical manufacturing Immunotherapy
オンライン･アクセス:	https://doi.org/10.1186/s12967-024-05197-5
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