CAR-T manufactured from frozen PBMC yield efficient function with prolonged in vitro production

Chimeric antigen receptor (CAR)-T cells are engineered to identify and eliminate cells expressing a target antigen. Current manufacturing protocols vary between commercial CAR-T cell products warranting an assessment of these methods to determine which approach optimally balances successful manufact...

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Autors principals:	Julieta Abraham-Miranda, Meghan Menges, Reginald Atkins, Mike Mattie, Justyna Kanska, Joel Turner, Melanie J. Hidalgo-Vargas, Frederick L. Locke
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-09-01
Col·lecció:	Frontiers in Immunology
Matèries:	chimeric antigen receptor T-cell CAR-T cell PBMC cryopreservation CAR-T cell in vitro expansion CAR-T cell cytokines production
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007042/full
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