Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma

Abstract Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclo...

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Detalhes bibliográficos

Principais autores:	Jenny Karlsson, Hiroaki Yasui, Adriana Mañas, Natalie Andersson, Karin Hansson, Kristina Aaltonen, Caroline Jansson, Geoffroy Durand, Naveen Ravi, Michele Ferro, Minjun Yang, Subhayan Chattopadhyay, Kajsa Paulsson, Diana Spierings, Floris Foijer, Anders Valind, Daniel Bexell, David Gisselsson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-10-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-53334-x
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