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GSPT1-specific protein degradation is effective in preclinical models of chemoresistant MYCN-amplified neuroblastoma

Abstract Background High-risk neuroblastoma (HR-NB) is associated with therapy-resistant relapse, and novel therapeutic strategies are needed. GSPT1 is a GTPase involved in protein translation whose disruption may offer therapeutic potential in translation-dependent cancers. Methods GSPT1 expression...

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Principais autores: Aleksandra Adamska, Hanna Chahin, Erick Andrés Muciño-Olmos, Javanshir Esfandyari, Kristina Aaltonen, Sofia Granados-Aparici, Joachim Tetteh Siaw, Katarzyna Radke, Chiara Lago, Paweł Pasikowski, Roman Pluta, Anna Sawicka, Przemysław Glaza, David Gisselsson, Samuel Navarro, Rosa Noguera, Joanna Majkut, Paweł Dobrzański, Sylvain Cottens, Michał J. Walczak, Daniel Bexell
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
GSPT1
MYCN
Neuroblastoma
Targeted protein degradation
Molecular glue
Chemoresistance
Online adgang:https://doi.org/10.1186/s13046-026-03647-0
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