Therapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade

In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against programmed death protein 1 (PD-1) and its ligand (PD-L1), or cytotoxic T lymphocyte antigen 4 (CTLA-4). In spite of these improve...

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Autors principals:	Carlo Genova, Chiara Dellepiane, Paolo Carrega, Sara Sommariva, Guido Ferlazzo, Paolo Pronzato, Rosaria Gangemi, Gilberto Filaci, Simona Coco, Michela Croce
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-01-01
Col·lecció:	Frontiers in Immunology
Matèries:	NSCLC PD-1/PD-L1 CTLA-4 tumor microenvironment (TME) immune checkpoint inhibitors dysfunctional T cells
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.799455/full
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