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ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

The immunophilin FKBP12 is a known inhibitor of type I BMP and TGF-β receptors that competes for binding with their substrate SMADs. FKBP12 and the close paralog FKBP12.6 additionally assemble with ryanodine receptors to control Ca<sup>2+</sup> release. Binding of FKBP12.6 to BMP/TGF-β receptors has...

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Principais autores: Eleanor Williams, Elise Riesebos, Georgina Kerr, Alex N. Bullock
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-01-01
Serier:Biomedicines
Fag:
BMP
kinase
FKBP12
FKBP12.6
ACVR1
ALK2
Online adgang:https://www.mdpi.com/2227-9059/9/2/129
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