ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

The immunophilin FKBP12 is a known inhibitor of type I BMP and TGF-β receptors that competes for binding with their substrate SMADs. FKBP12 and the close paralog FKBP12.6 additionally assemble with ryanodine receptors to control Ca²⁺ release. Binding of FKBP12.6 to BMP/TGF-β receptors has...

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Үндсэн зохиолчид:	Eleanor Williams, Elise Riesebos, Georgina Kerr, Alex N. Bullock
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2021-01-01
Цуврал:	Biomedicines
Нөхцлүүд:	BMP kinase FKBP12 FKBP12.6 ACVR1 ALK2
Онлайн хандалт:	https://www.mdpi.com/2227-9059/9/2/129
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!