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Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds

With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA topoisomerases, which are key enzymes that modify DNA and regulate DNA topology du...

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Principais autores: Josephine Geertsen Keller, Kamilla Vandsø Petersen, Karol Mizielinski, Celine Thiesen, Lotte Bjergbæk, Rosa M. Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Angela Trejo, Carme Masdeu, Concepcion Alonso, Birgitta R. Knudsen, Cinzia Tesauro
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2023-04-01
Serija:Pharmaceuticals
Teme:
human topoisomerase 1
<i>Mycobacterium smegmatis</i> topoisomerase 1
<i>Leishmania donovani</i> topoisomerase 1
monkeypox virus topoisomerase 1
enzyme activity
rolling circle amplification
Online dostop:https://www.mdpi.com/1424-8247/16/5/657
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