Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

Sponges biosynthesize α-methoxylated fatty acids with unusual biophysical and biological properties and in some cases they display enhanced anticancer activities. However, the antiprotozoal properties of the α-methoxylated fatty acids have been less studied. In this work, we describe the total synth...

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Główni autorzy:	Rosa M. Reguera, Christopher F. Prada, Raquel Alvarez-Velilla, Nashbly Montano, Néstor M. Carballeira, Rafael Balaña-Fouce
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2013-09-01
Seria:	Marine Drugs
Hasła przedmiotowe:	methoxylated fatty acids leishmania donovani 2-methoxy-5,9-eicosadienoic acid topoisomerase IB
Dostęp online:	http://www.mdpi.com/1660-3397/11/10/3661
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