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Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds

With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA topoisomerases, which are key enzymes that modify DNA and regulate DNA topology du...

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Principais autores: Josephine Geertsen Keller, Kamilla Vandsø Petersen, Karol Mizielinski, Celine Thiesen, Lotte Bjergbæk, Rosa M. Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Angela Trejo, Carme Masdeu, Concepcion Alonso, Birgitta R. Knudsen, Cinzia Tesauro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-04-01
coleção:Pharmaceuticals
Assuntos:
human topoisomerase 1
<i>Mycobacterium smegmatis</i> topoisomerase 1
<i>Leishmania donovani</i> topoisomerase 1
monkeypox virus topoisomerase 1
enzyme activity
rolling circle amplification
Acesso em linha:https://www.mdpi.com/1424-8247/16/5/657
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