Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

Soluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson’s disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of αSyn limits its accessibility, especially for antibody-based mo...

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Autors principals:	Inga Petersen, Muhammad Ilyas Ali, Alex Petrovic, Anders Jimmy Ytterberg, Karin Staxäng, Monika Hodik, Fadi Rofo, Sina Bondza, Greta Hultqvist
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2023-12-01
Col·lecció:	mAbs
Matèries:	Avidity multivalent antibodies Parkinson’s disease (PD) soluble aggregates alpha-Synuclein (αsyn)
Accés en línia:	https://www.tandfonline.com/doi/10.1080/19420862.2023.2256668
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