The α-Synuclein Monomer May Have Different Misfolding Mechanisms in the Induction of α-Synuclein Fibrils with Different Polymorphs

The aggregation of alpha-synuclein (α-Syn) is closely related to the occurrence of some neurodegenerative diseases such as Parkinson’s disease. The misfolding of α-Syn monomer plays a key role in the formation of aggregates and extension of fibril. However, the misfolding mechanism of α-Syn remains...

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Bibliografische gegevens

Hoofdauteurs:	Nannan Zhao, Qianqian Zhang, Fansen Yu, Xiaojun Yao, Huanxiang Liu
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2023-04-01
Reeks:	Biomolecules
Onderwerpen:	α-synuclein fibrils template-induced misfolding steered MD simulation DCCM secondary structure analysis residue interaction network
Online toegang:	https://www.mdpi.com/2218-273X/13/4/682
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