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Fibril core regions in engineered α-synuclein dimer are crucial for blocking of fibril elongation

Synucleinopathies like Parkinson's disease are neurodegenerative diseases which are associated with the deposition of fibrillar aggregates of the endogenous protein α-synuclein (α-syn). The inhibition of the elongation of α-syn fibrils is of great scientific interest and an option in the design of t...

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Bibliografske podrobnosti
Principais autores: Celina M. Schulz, Anne Pfitzer, Wolfgang Hoyer
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2023-01-01
Serija:BBA Advances
Teme:
Online dostop:http://www.sciencedirect.com/science/article/pii/S266716032300039X
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