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The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

Summary: How the opportunistic Gram-negative pathogens of the genus Achromobacter interact with the innate immune system is poorly understood. Using three Achromobacter clinical isolates from two species, we show that the type 3 secretion system (T3SS) is required to induce cell death in human macro...

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Автори: Keren Turton, Hannah J. Parks, Paulina Zarodkiewicz, Mohamad A. Hamad, Rachel Dwane, Georgiana Parau, Rebecca J. Ingram, Rebecca C. Coll, Clare E. Bryant, Miguel A. Valvano
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2023-08-01
Серія:Cell Reports
Предмети:
CP: Immunology
CP: Microbiology
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2211124723010239
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