Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production

IntroductionKlebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, the mechanisms underlying K. pneumoniae-induced sepsis and its pathogenesis remain unclear. Acute respiratory failure...

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Hlavní autoři:	Yuqi Zhou, Zhuodong Chai, Ankit Pandeya, Ling Yang, Yan Zhang, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-02-01
Edice:	Frontiers in Immunology
Témata:	Klebsiella sepsis pneumonia inflammasome caspase-11 NLRP3
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516120/full
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