Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

Aldose reductase (ALDR) is a critical protein involved in the pathogenesis of diabetic complications such as retinopathy, neuropathy, and nephropathy. Due to the activation of inflammatory and cytotoxic pathways under hyperglycemic conditions, ALDR has become an important target for therapeutic deve...

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Ngā kaituhi matua:	Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley-VCH 2025-12-01
Rangatū:	ChemistryOpen
Ngā marau:	aldose reductase inhibitors binding affinity diabetic neuropathy molecular dynamics simulations virtual screening
Urunga tuihono:	https://doi.org/10.1002/open.202500110
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!