Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

Aldose reductase (ALDR) is a critical protein involved in the pathogenesis of diabetic complications such as retinopathy, neuropathy, and nephropathy. Due to the activation of inflammatory and cytotoxic pathways under hyperglycemic conditions, ALDR has become an important target for therapeutic deve...

Descrición completa

Detalles Bibliográficos

Principais autores:	Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley-VCH 2025-12-01
Series:	ChemistryOpen
Assuntos:	aldose reductase inhibitors binding affinity diabetic neuropathy molecular dynamics simulations virtual screening
Acceso en liña:	https://doi.org/10.1002/open.202500110
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!