Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

Aldose reductase (ALDR) is a critical protein involved in the pathogenesis of diabetic complications such as retinopathy, neuropathy, and nephropathy. Due to the activation of inflammatory and cytotoxic pathways under hyperglycemic conditions, ALDR has become an important target for therapeutic deve...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley-VCH 2025-12-01
Edice:	ChemistryOpen
Témata:	aldose reductase inhibitors binding affinity diabetic neuropathy molecular dynamics simulations virtual screening
On-line přístup:	https://doi.org/10.1002/open.202500110
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!