Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

Summary: The Tousled-like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaperone and influence cell cycle progression and genome maintenance, yet the mechanisms underlying TLK-mediated genome stability remain uncertain. Here, we show that TLK loss results in severe ch...

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Bibliografski detalji

Glavni autori:	Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, Lars M. Koenig, Maria Sanchiz-Calvo, Simon J. Boulton, Travis H. Stracker
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2020-08-01
Serija:	Cell Reports
Teme:	TLK1 TLK2 ASF1 heterochromatin H3.3 telomeres
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2211124720309682
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