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Single-molecule analysis of subtelomeres and telomeres in Alternative Lengthening of Telomeres (ALT) cells

Abstract Background Telomeric DNA is typically comprised of G-rich tandem repeat motifs and maintained by telomerase (Greider CW, Blackburn EH; Cell 51:887–898; 1987). In eukaryotes lacking telomerase, a variety of DNA repair and DNA recombination based pathways for telomere maintenance have evolved...

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Autors principals: Heba Z. Abid, Jennifer McCaffrey, Kaitlin Raseley, Eleanor Young, Katy Lassahn, Dharma Varapula, Harold Riethman, Ming Xiao
Format: Artigo
Idioma:Inglês
Publicat: BMC 2020-07-01
Col·lecció:BMC Genomics
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Accés en línia:http://link.springer.com/article/10.1186/s12864-020-06901-7
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