Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints

Background: Tumor-associated macrophages (TAMs) depend on their amino acid metabolism to determine their properties and immune function and play important roles in the tumor microenvironment (TME). Although in previous studies, targeting amino acid metabolism to transform the protumor function of TA...

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Detalles Bibliográficos

Principais autores:	Beibei Ran, Lingjun Xiao, Yan Liu, Chenglin Zhang, Lingkai Kong, Yuxin Zhang, Xiaosong Gu, Chunping Jiang, Junhua Wu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-06-01
Series:	Journal of Advanced Research
Assuntos:	Tumor-associated macrophages (TAMs) Amino acid Metabolic reprogramming Tumor microenvironment (TME) Metabolic crosstalk Immunometabolic crosstalk
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2090123225007295
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