High-ammonia microenvironment promotes stemness and metastatic potential in hepatocellular carcinoma through metabolic reprogramming

Abstract Background Hepatocellular carcinoma (HCC) is a prevalent and aggressive form of liver cancer, characterized by frequent recurrence and metastasis, which remain significant obstacles to effective treatment. Ammonia accumulates in the tumor microenvironment of HCC due to dysfunction in the ur...

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Autores principales:	Renchao Zou, Sicong Jiang, Jiaqi Mei, Chen Chen, Jia Yu, Yanqiu Fu, Siyu Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer 2025-02-01
Colección:	Discover Oncology
Materias:	Hepatocellular carcinoma (HCC) Ammonia metabolism Tumor microenvironment Metabolic reprogramming
Acceso en línea:	https://doi.org/10.1007/s12672-025-01922-8
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