Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints

Background: Tumor-associated macrophages (TAMs) depend on their amino acid metabolism to determine their properties and immune function and play important roles in the tumor microenvironment (TME). Although in previous studies, targeting amino acid metabolism to transform the protumor function of TA...

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Hauptverfasser:	Beibei Ran, Lingjun Xiao, Yan Liu, Chenglin Zhang, Lingkai Kong, Yuxin Zhang, Xiaosong Gu, Chunping Jiang, Junhua Wu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-06-01
Schriftenreihe:	Journal of Advanced Research
Schlagworte:	Tumor-associated macrophages (TAMs) Amino acid Metabolic reprogramming Tumor microenvironment (TME) Metabolic crosstalk Immunometabolic crosstalk
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2090123225007295
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