Large-scale statistical mapping of T-cell receptor β sequences to human leukocyte antigens

IntroductionT-cell receptors (TCRs) interacting with peptides presented by human leukocyte antigens (HLAs) are the foundation of the adaptive immune system, but population-level analysis of TCR–HLA interactions is lacking.MethodsWe statistically associated approximately 106 public TCRβs to specific...

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Principais autores:	H. Jabran Zahid, Ruth Taniguchi, Peter Ebert, I-Ting Chow, Chris Gooley, Jinpeng Lv, Lorenzo Pisani, Mikaela Rusnak, Rebecca Elyanow, Hiroyuki Takamatsu, Wenyu Zhou, Julia Greissl, Harlan Robins, Jonathan M. Carlson
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Assuntos:	human leukocyte antigen T cell immunology T cell - HLA interaction T cell repertoire
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603730/full
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