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Structural basis of the TCR-pHLA complex provides insights into the unconventional recognition of CDR3β in TCR cross-reactivity and alloreactivity

Evidence shows that some class I human leucocyte antigen (HLA) alleles are related to durable HIV controls. The T18A TCR, which has the alloreactivity between HLA-B∗42:01 and HLA-B∗81:01 and the cross-reactivity with different antigen mutants, can sustain long-term HIV controls. Here the structural...

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Principais autores: Dan San, Jun Lei, Yang Liu, Baowei Jing, Xiang Ye, Pengcheng Wei, Chonil Paek, Yi Yang, Jin Zhou, Peng Chen, Hongjian Wang, Yongshun Chen, Lei Yin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-02-01
Serier:Cell Insight
Fag:
CD8+ T cell
HLA
TCR
Alloreactivity
HIV
Online adgang:http://www.sciencedirect.com/science/article/pii/S2772892722000736
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