Beyond sequence similarity: ML-powered identification of pHLA off-targets for TCR-mimic antibodies using high throughput binding kinetics

T-cell receptor mimic (TCRm) antibodies are an emerging class of tumor-targeting agents used in advanced immunotherapies such as bispecific T-cell engagers and CAR-T cells. Unlike conventional antibodies, TCRms are designed to recognize peptide – human leukocyte antigen (pHLA) complexes that present...

詳細記述

書誌詳細

主要な著者:	Alexander Sinclair, Stefan Krämer, Christoph Reinhart, Jennifer Stehle, Simon Schuster, Tobias Herz, Hoor Al Hasani, Pranav Hamde, Oliver Selinger, Joerg Birkenfeld
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis Group 2026-12-01
シリーズ:	mAbs
主題:	HLA MHC pHLA pMHC TCR-like antibody peptide-MHC complex
オンライン･アクセス:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2601360
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!