Beyond sequence similarity: ML-powered identification of pHLA off-targets for TCR-mimic antibodies using high throughput binding kinetics

T-cell receptor mimic (TCRm) antibodies are an emerging class of tumor-targeting agents used in advanced immunotherapies such as bispecific T-cell engagers and CAR-T cells. Unlike conventional antibodies, TCRms are designed to recognize peptide – human leukocyte antigen (pHLA) complexes that present...

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Detaylı Bibliyografya
Asıl Yazarlar:	Alexander Sinclair, Stefan Krämer, Christoph Reinhart, Jennifer Stehle, Simon Schuster, Tobias Herz, Hoor Al Hasani, Pranav Hamde, Oliver Selinger, Joerg Birkenfeld
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Taylor & Francis Group 2026-12-01
Seri Bilgileri:	mAbs
Konular:	HLA MHC pHLA pMHC TCR-like antibody peptide-MHC complex
Online Erişim:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2601360
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Beyond sequence similarity: ML-powered identification of pHLA off-targets for TCR-mimic antibodies using high throughput binding kinetics

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