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Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degeneration

Abstract Low back pain (LBP) is largely attributed to intervertebral disc degeneration (IVDD), of which the endplate changes are an important component. However, the alterations in cell fate and properties within the endplates during degeneration remain unknown. Here, we firstly performed the single...

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Uloženo v:
Hlavní autoři: Chenhao Shi, Yonggang Fan, Xiusheng Huang, Mingzhe Fan, Lantian Zhao, Huafeng Zhang, Shuangfei Ni
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2024-09-01
Edice:Scientific Reports
Témata:
Single-cell RNA sequencing
Cartilage endplate
Chondrocyte
Differentiation
Regulation
On-line přístup:https://doi.org/10.1038/s41598-024-71891-5
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