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Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degeneration

Abstract Low back pain (LBP) is largely attributed to intervertebral disc degeneration (IVDD), of which the endplate changes are an important component. However, the alterations in cell fate and properties within the endplates during degeneration remain unknown. Here, we firstly performed the single...

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Principais autores: Chenhao Shi, Yonggang Fan, Xiusheng Huang, Mingzhe Fan, Lantian Zhao, Huafeng Zhang, Shuangfei Ni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-09-01
coleção:Scientific Reports
Assuntos:
Single-cell RNA sequencing
Cartilage endplate
Chondrocyte
Differentiation
Regulation
Acesso em linha:https://doi.org/10.1038/s41598-024-71891-5
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