Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system

Abstract Background Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in target epigenome modifications. Successful germline transmission of a transg...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Takuro Horii, Sumiyo Morita, Mika Kimura, Izuho Hatada
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2022-12-01
Цуврал:	Epigenetics & Chromatin
Нөхцлүүд:	dCas9 Demethylation Epigenome editing piggyBac Silver–Russell syndrome SunTag
Онлайн хандалт:	https://doi.org/10.1186/s13072-022-00474-3
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!