Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system

Abstract Background Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in target epigenome modifications. Successful germline transmission of a transg...

Descripció completa

Dades bibliogràfiques

Autors principals:	Takuro Horii, Sumiyo Morita, Mika Kimura, Izuho Hatada
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2022-12-01
Col·lecció:	Epigenetics & Chromatin
Matèries:	dCas9 Demethylation Epigenome editing piggyBac Silver–Russell syndrome SunTag
Accés en línia:	https://doi.org/10.1186/s13072-022-00474-3
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!