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Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains

The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be less vulnerable to development of resistance. Teixoba...

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Principais autores: Kemin Tan, Min Zhou, Robert P. Jedrzejczak, Ruiying Wu, Raul A. Higuera, Dominika Borek, Gyorgy Babnigg, Andrzej Joachimiak
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-01-01
Colecção:Current Research in Structural Biology
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Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2665928X20300027
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