Role of isocitrate dehydrogenase 1 mutation-mediated D-2-hydroxyglutarate metabolic reprogramming in tumor immunoregulation and progress in related drug development
Mutations in isocitrate dehydrogenase 1 (IDH1) can abnormally produce the oncometabolite D-2-hydroxyglutarate (D2HG), which in turn remodels the tumor immune microenvironment. In recent years, it has become a key target in the research on the interaction between tumor metabolism and immunity. D2HG c...
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| Автори: | , , , , |
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| Формат: | Artigo |
| Мова: | Chinês |
| Опубліковано: |
Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2025-09-01
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| Серія: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Предмети: | |
| Онлайн доступ: | https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2025.09.016 |
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