Role of isocitrate dehydrogenase 1 mutation-mediated D-2-hydroxyglutarate metabolic reprogramming in tumor immunoregulation and progress in related drug development

Mutations in isocitrate dehydrogenase 1 (IDH1) can abnormally produce the oncometabolite D-2-hydroxyglutarate (D2HG), which in turn remodels the tumor immune microenvironment. In recent years, it has become a key target in the research on the interaction between tumor metabolism and immunity. D2HG c...

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Auteurs principaux:	YANG Quanjun, BAI Dingyuan, ZHOU Yuxuan, BAI Lu, GUO Cheng
Format:	Artigo
Langue:	Chinês
Publié:	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2025-09-01
Collection:	Shanghai Jiaotong Daxue xuebao. Yixue ban
Sujets:	isocitrate dehydrogenase 1 (idh1) d-2-hydroxyglutarate (d2hg) immunoregulation ivosidenib vorasidenib metabolic reprogramming
Accès en ligne:	https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2025.09.016
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