Isocitrate dehydrogenase mutations as potential tumour agnostic targets
The isocitrate dehydrogenase (IDH) family of proteins comprises three important metabolic enzymes that convert isocitrate to alpha ketoglutarate (α-KG) via oxidative decarboxylation. The IDH enzymes play important roles in epigenetic regulation, DNA repair, and cellular metabolism and biosynthesis....
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2026-03-01
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| coleção: | EJC Supplements |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S1359634926000029 |
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