Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells

Abstract Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR). We recently reported that the splicing inhibitor isoginkgetin (IGG) induced ATF4 protein along with several known ATF4-reg...

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Autores principales:	Erin van Zyl, John D. H. Stead, Claire Peneycad, Carole L. Yauk, Bruce C. McKay
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2024-10-01
Colección:	Scientific Reports
Materias:	Isoginkgetin Endoplasmic reticulum stress ATF4 Thapsigargin Unfolded protein response Integrated stress response
Acceso en línea:	https://doi.org/10.1038/s41598-024-74391-8
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