Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells

Abstract Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR). We recently reported that the splicing inhibitor isoginkgetin (IGG) induced ATF4 protein along with several known ATF4-reg...

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Bibliografski detalji

Glavni autori:	Erin van Zyl, John D. H. Stead, Claire Peneycad, Carole L. Yauk, Bruce C. McKay
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2024-10-01
Serija:	Scientific Reports
Teme:	Isoginkgetin Endoplasmic reticulum stress ATF4 Thapsigargin Unfolded protein response Integrated stress response
Online pristup:	https://doi.org/10.1038/s41598-024-74391-8
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